Please wait while the product information is retrieved.
We could not load this product.
Service Name | Induction Agents | Service Delivery Specification | Delivery Format:
• mDC (mature dendritic cell) induction service | IL-4, GM-CSF, LPS, TNF-α | 2 / 5 / 10 / 25 (million per run) | Cryopreserved
• iDC (immature dendritic cell) induction service | IL-4, GM-CSF | 2 / 5 / 10 / 25 (million per run) | Cryopreserved
PD-1 antibodies activate CD4+ T cells to secrete IFN-γ and IL-2 in a dose-dependent manner.
When mDCs induced from different donors were co-cultured in vitro with allogeneic PBMCs, all mDC preparations effectively activated T cells within the allogeneic PBMCs to secrete IFN-γ.
Figure: Data on mDC-induced IFN-γ secretion by allogeneic PBMC T cells
Figure: Dendritic cell induction data
Dendritic cells (DCs) are a population of professional antigen-presenting cells with an exceptionally strong capacity to activate naive T cells, and they are the initiators of the adaptive immune response. DCs exhibit remarkable plasticity: they can both drive immune activation and induce immune tolerance, and they perform multiple functions including antigen presentation, immune tolerance, T-cell polarization, B-cell regulation, and participation in innate immune responses. Owing to this plasticity, DCs have become a research focus in both basic and clinical studies of many diseases, such as transplantation, oncology, and autoimmune diseases.
Under normal conditions, DCs are present at low abundance, accounting for only about 1% of human peripheral blood mononuclear cells. To meet the needs of drug development, SailyBio provides induction services for immature and mature dendritic cells (iDC/mDC), facilitating the rapid advancement of related research.
SailyBio's dendritic cell induction service covers two specifications, immature DCs (iDC) and mature DCs (mDC). The induced products can be used in DC–T cell co-culture, MLR assays, and vaccine evaluation, supporting studies in tumor immunology, transplantation, and autoimmune diseases.