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Industrialized cell isolation and preparation workflows with full-process quality control management.
Stable and compliant immune cell sourcing shortens experimental cycles and ensures consistency of conclusions.
Based on a donor pool of more than 2,000 donors, donors with stronger immune responses can be pre-screened, accelerating development and reducing R&D costs.
Safe and compliant project services that satisfy the documentation requirements for new drug application regulatory submissions.
Customized services can be provided in accordance with client needs, with guaranteed delivery timelines.
PD-1 antibodies dose-dependently activate CD4+ T cells to secrete IFN-γ and IL-2.
Related services: premium PBMC isolation service, dendritic cell (iDC/mDC) induction service, and CD4+ cell sorting service.
Figure: Schematic illustration of the MLR assay system
Figure: PD-1 antibody MLR activation of IFN-γ/IL-2 data
Recapitulating in vitro the capacity of dendritic cells to activate or suppress T-cell proliferation and cytokine secretion is a very important mechanism of action (MOA) for drugs that exert agonistic or antagonistic effects.
SailyBio provides MLR (mixed lymphocyte reaction) assay services: a DC–T cell co-culture system is established in vitro for immunomodulatory assessment, and a PD-1 antibody MLR case study validates the dose-dependent IFN-γ/IL-2 activation effect, meeting the need for MOA verification of immunomodulatory drug classes.
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